๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Generalized eruptive histiocytosis
Generalized eruptive histiocytosis
Generalized eruptive histiocytosis (generalized eruptive histiocytoma) is a rare condition characterized by recurrent, asymptomatic, symmetrical crops of small (1โ10โฏmm) tan, erythematous or blue-red, firm, discrete papules or rarely nodules on the face, trunk, and arms, and occasionally the legs (Fig. 29.298).43โ50 Warty lesions and lesions in a seborrheic distribution are exceptional.44,48,51,52 Mucous membranes, palms, and soles are generally spared.2,6,8,9 Visceral involvement is not a feature and lipids are normal.49 Lesions may last from months to years.6 Spontaneous resolution to leave hyperpigmented atrophic anetoderma-like macules is common, with complete resolution of all lesions.48,49 Adults are most often affected, with rare cases in children.51โ60 Umbilicated lesions in children mimic molluscum contagiosum.55,56,60 Two patients have been described in which an early presentation as generalized eruptive histiocytoma evolved into typical XD, emphasizing the considerable overlap in the non-X group of histiocytosis.55,56
Fig. 29.298 Generalized eruptive histiocytoma: this middle-aged patient developed hundreds of asymptomatic papules on the trunk and limbs. By courtesy of R.M. Mackie, MD, Western Infirmary, Glasgow, UK.