๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Cutaneous Castleman disease
Cutaneous Castleman disease
Clinical features Castleman disease (CD) (giant lymph node hyperplasia, angiofollicular lymph node hyperplasia) is a rare B-cell lymphoproliferative disorder mainly involving lymph nodes, with unicentric (usually no systemic symptoms) or
multicentric (usually with systemic symptoms) involvement and associated in a percentage of cases with HIV/AIDS and HHV8 infection.1 However, not all cases associated with HHV8 infection are HIV positive. Two main histologic variants occur, namely, the hyaline vascular type predominantly seen in unicentric disease and the plasma cell type mainly seen in multicentric disease and in cases associated with HIV infection. Cutaneous involvement in CD is exceptional, with only a handful of cases reported and mainly associated with the multicentric plasma cell variant of the disease. Cutaneous presentation is with papules, nodules, or plaques and involvement has been reported on trunk and limbs and rarely on the face.2โ9
1487 Inflammatory pseudotumor of the skin
Pathogenesis and histologic features CD appears to be due to secretion of IL-6 both in idiopathic cases and in those associated with HHV8.1,10 In cutaneous lesions, there is a dermal and sometimes subcutaneous infiltrate composed mainly of polyclonal plasma cells with no cytological atypia.2,3,5โ7 Increased vascularity is usually present in the background. In rare cases, the appearance is more similar to that seen in the hyaline vascular type of disease, with bands of sclerosis surrounding an infiltrate with atrophic germinal centers and expanded mantle zones in an onion ring pattern.4,8