๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Prognostic indicators โ Differential diagnosis
Differential diagnosis
Amelanotic spindled cell melanoma may be histologically indistinguishable from other cutaneous spindled cell tumors including leiomyosarcoma, spindled cell squamous carcinoma, atypical fibroxanthoma, and even dermatofibrosarcoma protuberans. In such cases, the use of an appropriate panel of immunohistochemical reagents, including antibodies to S100 protein, SOX10, HMB-45 or MART-1, pan-cytokeratin, AE1/AE3, smooth muscle
1328 Melanoma
actin (SMA), and CD34, is often essential. Similarly, highly pleomorphic, amelanotic epithelioid melanoma sometimes has to be distinguished from anaplastic carcinoma and occasionally anaplastic lymphoma. The use of antibodies to keratins, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), leukocyte common antigen (LCA), T- and B-cell antigens, and CD30 may be necessary to achieve a definitive diagnosis.