๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Neurofibroma
Neurofibroma
Clinical features Neurofibroma is perhaps the commonest tumor of nerve sheath origin.1โ3 In the majority of cases it is solitary and unassociated with any other systemic features; however, multiple lesions are not rare and form a cardinal feature of neurofibromatosis type I (von Recklinghausen disease). In its sporadic form, this tumor presents in a somewhat younger age group than schwannoma, as a polypoid or nodular soft lesion; in contrast to the latter it is frequently cutaneous and may arise anywhere in the integument (Figs 35.323 and 35.324). Cases of multiple lesions induced by radiotherapy have been reported.4,5 Isolated cutaneous tumors tend to be sporadic. Deeper and larger lesions are much more concerning for syndromic association, especially when they display plexiform features.
Fig. 35.323 Neurofibroma: erythematous nodule with surrounding simple lentigines. From the collection of the late N.P. Smith, MD, Institute of Dermatology, London, UK.