๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Cutaneous myxoma
Cutaneous myxoma
Clinical features Cutaneous myxomas (also known as cutaneous myxoid cysts) are rare and are characterized by a solitary small painful lesion that occurs most often on the hand (especially the fingers) of adults and shows a marked predilection for females.1 Local recurrence is common. Multiple lesions are exceptional and in one reported case there was transepidermal elimination of myxoid material.2 A case presenting on the knee joint has been documented.3
Rarely, cutaneous myxomas can be associated with Carney complex (various endocrine and non-endocrine tumors and cancer) which is caused by germline mutations of PRKAR1A in the cyclic AMP-dependent protein kinase signaling pathway.4 Cardiac and breast myxomas and myxomas at other sites are more common than dermal myxomas in Carney complex. The relationship of cutaneous myxomas and the superficial angiomyxomas described below is poorly delineated in the literature and likely overlap exists.
Histologic features Histologic features consist of a poorly circumscribed dermal lesion composed of plump stellate and spindle-shaped cells with no atypia surrounded by an abundant myxoid matrix. Lesional cells are negative for S100 protein and actin. Whether these swellings are related to focal cutaneous mucinosis is uncertain.