๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
IgG4-related disease
IgG4-related disease
Clinical features IgG4 is the least common of the four IgG subclasses of antibody. It has a low affinity for target antigen and does not activate compliment. It plays a role in parasitic infection and allergic conditions such as asthma, eczema, as well as certain bullous disorders.1 IgG4-related disease (IgG4-RD) was first recognized following studies of autoimmune pancreatitis.2,3 A similar disease process was subsequently documented at many other sites, and many previously recognized conditions are now acknowledged to lie within the spectrum of IgG4-RD.4 The latter include salivary gland lesions such as Mikulicz syndrome and Kuttner tumor, Reidels thyroiditis, and eosinophilic angiocentric fibrosis of orbit and upper respiratory tract.4 A recent