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Keratoacanthoma
Keratoacanthoma
Clinical features Keratoacanthoma is a rare lesion with fewer than 20 reported cases1 that grows rapidly, over a period of 3 to 4 weeks. It most frequently occurs at the temporal limbus. The lesion is a white nodular mass with a hyperkeratotic area and surrounded by dilated blood vessels, and may be clinically indistinguishable from squamous cell carcinoma.
Histologic features Keratoacanthoma of the conjunctiva shows similar features to that of the skin, with crateriform architecture filled with keratin. The surrounding epithelium is acanthotic and hyperkeratotic with focal parakeratosis and dyskeratosis. A chronic inflammatory infiltrate is often present at the base. Cytological atypia is usually mild,1,2 but some cases may demonstrate marked atypia, causing difficulty in distinguishing from well-differentiated squamous cell carcinoma.