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Cytomegalovirus infections
Cytomegalovirus infections
Clinical features Antibody studies suggest that most people have been exposed to CMV.1 Generally, an asymptomatic infection ensues. CMV infection, however, may result in clinical features under a variety of circumstances. These include neonatal lesions, an infectious mononucleosis-like disease in adults, or a manifestation of disseminated disease in immunocompromised patients.2,3 An in-depth review of the literature revealed that severe visceral CMV infection in apparently immunocompetent individuals might not be as
Pathogenesis and histologic features In addition to maternally derived infections, there is also some evidence to suggest a venereal mode of spread.64 In the immunocompromised patient, CMV infections represent an acquired phenomenon or reactivation of a latent focus.47 In immunosuppressed transplant recipients, infection occurs predominantly after the first month post-transplantation and is the result of either primary infection, reinfection, or reactivation of latent disease.49 A high antigen-specific T-cell response to CMV is responsible for chemokine-mediated endothelial cell damage.65
846 Infectious diseases of the skin