๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Cole disease
Cole disease
Clinical features Cole disease is characterized by a punctate keratoderma with guttate hypopigmentation.1 The disease manifests during the first year of life. Affected individuals present with a mild punctuate keratoderma. In addition, they develop sharply demarcated irregular macules with varying degrees of