๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Carcinogen-induced melanoma
Carcinogen-induced melanoma
Early approaches utilizing the initiating carcinogen 7,12-dimethylbenz[a] anthracene (DMBA) were utilized to model squamous cell carcinoma and other neoplasms in mice4 and hamsters. It was noted that hamsters also developed highly pigmented melanocytic tumors.5 Many of these tumors grew slowly, and it was at times difficult to determine whether the lesions were benign or fully malignant. Ultraviolet (UV) irradiation is perhaps the most important environmental exposure leading to melanoma in humans, and it has been utilized to model skin cancer in non-genetically engineered mice. Chronic, repetitive exposure to UV light resulted in cutaneous malignant tumors, most of which represented poorly differentiated squamous cell carcinoma, occasional cutaneous sarcomas, and rarely resulted in melanoma.6