๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Infectious diseases
Infectious diseases
Laboratory mice today are usually re-derived by cesarean section or embryo transfer, raised on microbiologically defined (specific pathogen free [SPF])
A
C
1901 Coat color genetics
hematoxylin and eosin (H&E)-stained sections and confirmed using antibodies directed against smooth muscle actin for vascular smooth muscle or platelet/endothelial cell adhesion molecule 1 (PECAM1, formerly called CD31).2
Lymphatics are often overlooked in the mouse because in the skin, these appear as small slits below the epidermis and parallel to the angle of the hair follicle within the dermis. Once one recognizes these structures, they are easy to identify in routine histologic sections. However, antibodies directed against lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1) clearly labels the lymphatic endothelial cells.3 The C3H/HeJ mouse spontaneously develops alopecia areata,4 which has remained the model of choice for this human disease for two decades.5 Evaluation of skin in mice with alopecia areata as the disease progresses revealed dilation of the cutaneous lymphatics.3
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