๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Nodular fasciitis
Nodular fasciitis
Clinical features Nodular fasciitis is a benign proliferation of fibroblasts and myofibroblasts that rarely occurs in the ocular region, including orbit and eyelid. Eight cases of epibulbar nodular fasciitis have been reported in the literature.1 Although it was thought to be a response to repeated trauma or inflammation, it is now thought to be a transient neoplasm associated with a MYH9-USP6 gene fusion.2โ4 The most common locations are at extraocular
muscle insertions, and at the limbus with involvement of the cornea.1,2 Epibulbar nodular fasciitis is thought to originate from Tenon capsule.5
Histologic features Nodular fasciitis is a round or oval unencapsulated nodule composed of spindled to stellate fibroblasts and smooth muscle actin-positive myofibroblasts in a myxoid to fibrous background arranged haphazardly in a โtissue cultureโ appearance. Extravasated red blood cells and scant inflammatory cells may be present. Numerous mitotic figures may lead to misdiagnosis as sarcoma.
1383 Histiocytic tumors
Histologic features Schwannoma is composed of spindle-shaped cells with eosinophilic cytoplasm and fascicular or palisade arrangement. There is no cytological atypia or atypical mitoses. By immunohistochemistry, tumor cells are strongly positive for S100 protein.1