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Oncocytoma
Oncocytoma
Clinical features Oncocytoma is a benign tumor that usually arises in the caruncle of older, female patients (Fig. 27.13). Patients typically present with a fleshy, subepithelial, orange-red or dark blue mass, often with intralesional cysts.
Ultrasound biomicroscopy may show mixed solid and cystic components.1 Oncocytoma may also arise from lacrimal sac, lacrimal gland, or eyelid.
Histologic features Oncocytoma is a circumscribed nodule of epithelial cells with abundant, granular eosinophilic cytoplasm arranged in nests, cords, or sheets that may form glandular or ductal structures (Fig. 27.14). Carcinomatous transformation is very rare.1
Fig. 27.13 Oncocytoma: subepithelial, fleshy orange-pink lesion in the caruncle.
Fig. 27.14 Oncocytoma: histology of a lesion in the substantia propria of the caruncle shows large cells with eosinophilic cytoplasm arranged in glandular structures.