๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Nodular melanoma
Nodular melanoma
By definition, nodular melanoma has no evident preceding radial growth phase, its growth pattern appearing vertical from inception. Such a tumor, therefore, does not show an intraepidermal melanocytic proliferation beyond three epidermal ridges on either side of the tumor mass (Figs 26.37 and 26.38). This histologic pattern is usually, but not always, seen in the same anatomic distribution as superficial spreading melanoma; these have overlapping genomic features, but some regard them as distinct entities.135
Fig. 26.37 Nodular melanoma: this variant is typically sharply circumscribed.