๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Cutaneous focal mucinosis
Cutaneous focal mucinosis
case occurring on the lateral aspect of the knee has been described.3 Occasionally, lesions are multiple.4,5 Cutaneous myxoid cysts may present at any age and are more common in females. The surface is usually smooth, although verrucous variants are occasionally encountered. The cyst contains clear, yellow, viscous fluid. Lesions are often painful or tender. Myxoid cyst involving the proximal nail fold can be associated with longitudinal grooving of the nail.6 Although the precise cause is not well elucidated, underlying osteoarthrosis is sometimes evident, and repetitive trauma is proposed to be one possible mechanism.1,4
Histologic features The cyst is devoid of any lining and consists of a large pool of mucin containing spindled/stellate fibroblasts with prominent cytoplasmic processes
Clinical features Cutaneous focal mucinosis presents as an asymptomatic, usually solitary, dermal papule or nodule most commonly on the face, neck, trunk, or extremities of adults.1โ6 A case involving the areola has been recently reported.7 It is not seen in relation to the joints of the hands, feet, or wrists. The lesion is usually dome-shaped, white or flesh-colored and sometimes has an erythematous halo.2 Occasional verrucous variants have been documented.1 There is usually no evidence of an associated thyroid abnormality. Exceptional cases, however, are associated with reticular erythematous mucinosis or scleromyxedema.8 Multiple lesions are rare.9
Histologic features The lesion is usually located in the mid and upper dermis, often separated from the epidermis by a grenz zone of dermal sparing.2 It consists of a localized, but usually poorly delineated, focus of mucin deposition containing increased numbers of spindle-shaped cells and stellate fibroblasts
625 The mucinoses