๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Idiopathic calcinosis cutis
Idiopathic calcinosis cutis
Clinical features There are six main clinical types of calcinosis in which there is usually no known predisposing condition:
โข In calcinosis universalis, there is progressive deposition of calcium in the skin and subcutaneous tissue, producing discharging hard nodules and plaques very similar clinically to those seen in metastatic calcification.69โ72 This condition has been associated with dermatomyositis, lupus erythematosus, scleroderma, and chronic graft-versus-host disease.73โ77 Therefore some cases may represent manifestations of other diseases in which the acute phase was not diagnosed.
โข In contrast, idiopathic calcinosis may occur as a solitary nodule on the extremities and face, particularly the eyelids (subepidermal calcified nodule, cutaneous calculus).78,79 It usually presents in early childhood and is more common in males; the majority of the nodules are hyperkeratotic and tender on palpation. Rarely, it may be present at birth and occasionally multiple lesions are present.80
โข Localized idiopathic dermal calcinosis may also occur as a solitary nodule on the limbs.81,82 The fingers and elbows are particularly affected.1 An equivalent lesion, designated oral mucosal calcified nodule, which affects the gingiva, tongue, and palate has been documented.83โ86