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Pyoderma gangrenosum
Pyoderma gangrenosum
This is a rare genital affliction, including the variant superficial granulomatous pyoderma1 that can affect the penis and scrotum in adults and children. In children the anogenital area is a site of predilection in addition to the head and neck. Genital pyoderma gangrenosum may occur following local trauma such as urological surgery1,2 or treatment for cancer.3 A case has been reported in association with the oncological use of pazopanib (a selective multi-tyrosine kinase inhibitor that blocks tumor growth and inhibits angiogenesis).4 It may complicate ulcerative colitis5 or chronic lymphocytic leukemia, or may be idiopathic.6โ9 In idiopathic cases, the diagnosis is frequently delayed because it is not included in the differential by the clinician
494 Diseases of the anogenital skin
in pursuit of a diagnosis of cancer or infection. Pathologists may receive biopsies without this possibility being mentioned to them.10
Pyoderma gangrenosum of the vulva has been reported after an obstetric laceration.11
Histologic features The histologic features are non-specific identical to those seen in lesions elsewhere.