๐ ็ธฝ็ฎ้ ๏ฝ ๐ ่ฑๆๅๆ๏ผๆฌ็ฏ๏ผ ๏ฝ ๐ ๅฎๆด็ฟป่ญฏ ๏ฝ โญ ็ฒพ่ฏ็ญ่จ
Pemphigus vulgaris
Pemphigus vulgaris
Clinical features P. vulgaris particularly affects the middle-aged (onset typically at 40โ60 years of age), although occasionally (up to 2.6%) children are affected.1โ8 Self-limiting neonatal disease through transplacental transfer of maternal autoantibodies has also rarely been documented (see pathogenesis).9โ15 The disease begins in the mouth (Figs 5.2 and 5.3) in 50โ70% of patients with painful erosions or bullae and, after a period of weeks or months, the blisters spread to involve the skin.16โ22 Oral lesions most commonly affect the buccal, palatine, and gingival mucosae.1,19โ23 P. vulgaris is only rarely confined to the skin.24,25
Fig. 5.2 Pemphigus vulgaris: painful erosions are present on the buccal mucosa. By courtesy of R.A. Marsden, MD, St Georgeโs Hospital, London, UK.